MacGyver, a reimagining of the classic series, is an action-adventure drama about 20-something Angus "Mac" MacGyver, who creates a clandestine organization within the U.S. government where he uses his extraordinary talent for unconventional problem solving and vast scientific knowledge to save lives. Joining his team on high-risk missions around the globe is maverick former CIA agent Jack Dalton and Patricia Thornton, ex-field agent turned director of operations and Riley Davis, an unpredictable computer hacker with a chip on her shoulder. At home, MacGyver is entertained by his ambitious roommate, Wilt Bozer. Under the aegis of the Department of External Services, MacGyver takes on the responsibility of saving the world, armed to the teeth with resourcefulness and little more than bubble gum and a paper clip.
The team has to help a pro-democratic leader in Ecuador live long enough to get to election day, by transporting a heart to him along with the doctor who will put it in. Meanwhile, Wilt sets out to find Jack's stolen belongings.
While the team steal a rare painting to lure an art dealer and terrorist financier out of hiding, Wilt finds a mystery while attending training. Meanwhile, Riley's father approaches her about becoming part of her life again.
The assassins that Murdoc has been gathering turn against him and sell him to Phoenix. However, Murdoc's mentor Nicholas Helman wants Murdoc dead and will do whatever it takes to kill him. Meanwhile, Jack considers his relationship with Diane when she moves back to LA.
MacGyver, Leanna, Riley and Bozer pose as honeymoon couples at a resort in order to gain information about a Serbian war criminal from his newly married son. Also, Bozer wonders if Matty knows about his relationship with Leanna, and Jack recruits Elwood to help him break into Matty's home.