Described as a sort of comedic X-Files, Ghosted centers on Leroy Wright, a cynical, hilarious skeptic, and Max Allison, a genius "true believer" in the paranormal, who are hired by the Underground Investigative Service to look into the rampant "unexplained" activity in Los Angeles — all while uncovering a larger mystery that could threaten the existence of the human race.
When a key member of The Bureau Underground – a top secret government agency – goes missing, Leroy, a cynical former detective, and Max, a genius "true believer" in the paranormal, are recruited to find him. The two polar opposites must work together to find the agent, while uncovering possible alien activity and chilling "unexplained" paranormal events in their own city of Los Angeles.
Leroy and Max take Jermaine trick-or-treating, although Jermaine hopes they'll drop him off at a party instead. The party becomes the least of their worries when Jermaine is infected with a zombie-esque virus by a demon cat. Meanwhile, Halloween is a busy night, full of paranormal activity, for LaFrey, Annie and Barry at the Bureau Underground.
With the encouragement of Max, Leroy romantically pursues a female cop, while they work on-site at a local resort. As the pair search for the culprit behind a string of murders, Captain Lafrey has Annie and Barry investigate her daughter, who may be sneaking behind her back with a boy.
While Captain Lafrey is out, Annie installs a smooth-talking Artificial Intelligence, "Sam," to manage the office, but Max and Leroy are put to the test when "Sam" turns out to be an evil and powerful force trying to take down the Bureau Underground. All the while, Max is jealous when Leroy makes a new friend.