Described as a sort of comedic X-Files, Ghosted centers on Leroy Wright, a cynical, hilarious skeptic, and Max Allison, a genius "true believer" in the paranormal, who are hired by the Underground Investigative Service to look into the rampant "unexplained" activity in Los Angeles — all while uncovering a larger mystery that could threaten the existence of the human race.
When a key member of The Bureau Underground – a top secret government agency – goes missing, Leroy, a cynical former detective, and Max, a genius "true believer" in the paranormal, are recruited to find him. The two polar opposites must work together to find the agent, while uncovering possible alien activity and chilling "unexplained" paranormal events in their own city of Los Angeles.
Leroy and Max take Jermaine trick-or-treating, although Jermaine hopes they'll drop him off at a party instead. The party becomes the least of their worries when Jermaine is infected with a zombie-esque virus by a demon cat. Meanwhile, Halloween is a busy night, full of paranormal activity, for LaFrey, Annie and Barry at the Bureau Underground.
With the encouragement of Max, Leroy romantically pursues a female cop, while they work on-site at a local resort. As the pair search for the culprit behind a string of murders, Captain Lafrey has Annie and Barry investigate her daughter, who may be sneaking behind her back with a boy.
When Max and Leroy investigate a bizarre incident at an elite country club, they both get a little too invested in their covers and find themselves at odds. Also, Annie accompanies them on the mission, as she frequented many country clubs in her youth.
While Captain Lafrey is out, Annie installs a smooth-talking Artificial Intelligence, "Sam," to manage the office, but Max and Leroy are put to the test when "Sam" turns out to be an evil and powerful force trying to take down the Bureau Underground. All the while, Max is jealous when Leroy makes a new friend.
When a pair of smug actors, Chaz and Jared, from the ghost-hunting show "Ghost Studz," accidentally stumble upon real paranormal activity, Max and Leroy must go undercover on set at an abandoned mental hospital to save them. Leroy resents the "perks" the actors get with their fame, realizing he and Max will never enjoy the same benefits working in a top-secret bureau. Meanwhile, Barry demands some perks of his own.
Max and Leroy invite Annie to tag along on their next case, as she is an expert on the killer creature they are trying to find, but Max's survival skills are put to the test when they lose their way in the woods. Back at The Bureau Underground, Barry proves himself an asset in solving Captain LaFrey's dating struggles.
While trying to prove their worth to Captain LaFrey and the rest of The Bureau Underground, Leroy and Max finally have a lead on the whereabouts of Agent Checker. Leroy finds himself in the odd position of being the believer when Max loses faith that they have what it takes.