Outcast follows Kyle Barnes, a young man who has been plagued by possession since he was a child. Now an adult, he embarks on a journey to find answers but what he uncovers could mean the end of life on Earth as we know it.
With the help of Chief Giles, Kyle pursues a more aggressive strategy to deal with the possession problem in Rome – and discovers a new foe. Reverend Anderson faces the consequences of his rash choices. Megan resorts to desperate measures to deal with her grief over her husband.
A dangerous fugitive on the loose threatens the town of Rome, as well as Reverend Anderson's sanity. Kyle struggles with a new understanding of where his powers – and his curse – originated. Megan and Holly attempt to rebuild their lives.
Kyle gets closer to finding Sidney, while Anderson discovers an unexpected potential ally. A prominent member of the Rome community is revealed to be an agent of the possessed, and few characters will escape his plan unscathed.
Kyle attempts to get his family to safety as the town of Rome becomes increasingly overrun by the possessed. Anderson takes Megan under his wing, bringing her to find solace in an unlikely place. Chief Giles realizes his wife has been resorting to desperate measures.
Kyle faces the mysteries behind his powers. Reverend Anderson finally confronts Sidney as Doctor Park's plans grow in scale. Megan makes an unlikely friend – one who will prove dangerous. Chief Giles tries to defend himself and his wife from the tide of the possessed in Rome.
Kyle and Anderson face down Sidney – until an unexpected threat intervenes. Megan leaves the relative safety of the backwoods church, and danger quickly finds her. Tragedy strikes the Giles family. An unexpected stranger rivets Kyle's attention.
Kyle reluctantly joins forces with a mysterious stranger in an attempt to end the possession threat once and for all, but fears the man may be hiding something. Megan struggles to escape her captors. Reverend Anderson shares an unexpected source of strength with his old friend, Chief Giles.