Sink your teeth into meaty drama and intrigue with House, FOX's take on mystery, where the villain is a medical malady and the hero is an irreverent, controversial doctor who trusts no one, least of all his patients.
House has spent the last year in jail after ramming his car into Cuddy's house. When a fellow inmate becomes ill, House tries to help him while encouraging the young prison clinic doctor, Jessica Adams to trust his diagnosis.
A surprising visitor makes House an offer he can't refuse by giving him the opportunity to help the Princeton Plainsboro team treat a unique patient in order to save the life of an organ recipient being treated by Wilson. Although House finds himself back on familiar ground, he quickly realizes that much has changed since he left, and he is forced to work on the case with smart yet timid resident Dr. Chi Park.
A CEO falls mysteriously ill just days before he signs a contract that would relocate his company's entire labor force to China. Meanwhile, Park prepares for her hearing with the Princeton Plainsboro Disciplinary Committee chaired by Foreman.
A man well-respected in his community suddenly collapses, and in the process of diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life. Meanwhile, House will stop at nothing to manipulate Taub into taking a DNA test to prove he is the father of his two six-month-old daughters.
A teenage boy attempting to follow in his late father's footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.
The team learns that their 14-year-old patient is suffering from more than teen angst when her physical symptoms worsen. Despite Foreman's firm opposition, House becomes obsessed with solving a peculiar case of a deceased four-year-old patient, which gets him into serious trouble.
A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. Wilson becomes obsessed with proving that House is hiding something in his home, Park slowly comes out of her social shell and Foreman's lack of romantic relationships piques the interest of Taub and Chase.
An Alzheimer's patient visits Princeton Plainsboro as part of a hospital sanctioned drug trial, but when he inexplicably suffers from violent vomiting and an increasingly explosive temper, the team begins to unravel a deeper marriage conflict between the patient and his dutiful wife. Meanwhile, House and Foreman butt heads, and Wilson treats a patient who claims to be in a chaste marriage.
The team treats an underage and homeless female patient, but when her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. Meanwhile, Taub has a difficult time connecting with his infant daughters and House threatens to exploit Foreman's relationship with a married woman.
When a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman's former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.
Chase takes on a patient, Moira, who is a cloistered nun on the verge of making her life-changing vows, and through the treatment process, he and Moira form a unique connection that tests their faith and reason. Meanwhile, House and Taub try to remain one step ahead of each other's pranks.
A marriage counselor collapses during a speaking engagement, but when he is put under close evaluation, the team notice changes in his behavior that conflict with his motivational message on the roles of men and women. Meanwhile, House and his Ukrainian "wife" Dominika, make a deal to convince Immigration that they are a happily married couple.
House and the team battle to save a successful, independent blind man who is struck down by a mysterious illness, just prior to him asking for his girlfriend's hand in marriage. Meanwhile, House's mother unexpectedly arrives at Princeton Plainsboro to inform him of her new beau.
The team treats an Army veteran charged with treason after he leaked classified information. Meanwhile, Adams suspects House may be sick, so she recruits Wilson and the other team members to plan an intervention and investigate his illness.
House and the team take on the case of a 22-year-old minor league hockey player who collapsed while coughing up blood after a fight on the ice. Meanwhile, House drops a bomb on Wilson, and Chase offers to help Park change her living arrangement.
House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker, since his current favorite, Emily, has decided to get married and leave the business.
When the team takes on the case of Emily, a six-year-old girl who has numerous preexisting health problems, they must work with her mother Elizabeth, who happens to be doctor herself, specializing in her daughter's condition. Meanwhile, House and Wilson take a little vacation.
The team takes on the case of Dr. Peter Treiber, a pathologist at Princeton-Plainsboro Teaching Hospital who knows too much about the hospital staff to trust any of the physicians. The only person he does respect is House, who has mysteriously gone missing. With House in absentia, the team has to figure out how to treat Treiber while making him believe that House is calling all the shots.
The team takes on the case of Derrick, a 19-year-old college student who had a mysterious nose bleed during cheer leading practice, and discovers that his health issues are likely both physiological and psychological.