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It's June 1967, and the Order of St Raymond Nonnatus are celebrating a very special milestone birthday. It has been 100 years since the Order first arrived in Poplar. When Sister Julienne is unable to organise the celebrations, Shelagh brings the community together for what will be a joyous occasion.

While tending to a patient who has tuberculosis, Sister Frances and Nancy learn that some residents have become increasingly frustrated by the presence of meths drinkers in the area. As local councillor, Violet must balance her professional and personal views in how best to tackle the issue. However, Nancy begins to see past the community's fear and recognises the plight of these homeless addicts.