Uncle stars stand-up comedian and singer/songwriter Nick Helm as Andy, a dissolute out-of work musician who forges an unlikely alliance with his 12-year-old nephew Errol after being morally blackmailed into looking after him by his chaotic sister Sam – all on the day Andy was planning to kill himself.
It's eighteen months since Andy (Nick Helm) found out that he was going to be a father, and the baby he's never met is haunting his nightmares. But is he ready to be a dad? And why do people count baby ages in months anyway? As he tries to work up the nerve to confront Teresa (Raquel Cassidy) about their child, he's distracted by an offer from a record company executive that puts his artistic integrity to the test and makes him think about what really matters. Meanwhile Errol (Elliot Speller-Gillot) butts heads with Bruce (Daniel Lawrence Taylor) as he figures out how to live under the same roof as his mum's new partner and Sam (Daisy Haggard) contemplates motherhood.
Andy makes a start on his new career, but finds songwriting for a boy band more difficult than he'd imagined. Is he past it?
Worried his new job may be over before it's started, he takes Errol to work for moral support. But Errol has more than just music on his mind. Now 15, his hormones are raging and he concludes that he needs to find a girlfriend - but things soon get competitive when he and Uncle Andy vie for the attentions of Lex (Kae Alexander).