Uncle stars stand-up comedian and singer/songwriter Nick Helm as Andy, a dissolute out-of work musician who forges an unlikely alliance with his 12-year-old nephew Errol after being morally blackmailed into looking after him by his chaotic sister Sam – all on the day Andy was planning to kill himself.
It's eighteen months since Andy found out that he was going to be a father, and the baby he's never met is haunting his nightmares. But is he ready to be a dad? And why do people count baby ages in months anyway? As he tries to work up the nerve to confront Teresa about their child, he's distracted by an offer from a record company executive that puts his artistic integrity to the test and makes him think about what really matters. Meanwhile Errol butts heads with Bruce as he figures out how to live under the same roof as his mum's new partner and Sam contemplates motherhood.
Andy makes a start on his new career, but finds songwriting for a boy band more difficult than he'd imagined. Is he past it?
Worried his new job may be over before it's started, he takes Errol to work for moral support. But Errol has more than just music on his mind. Now 15, his hormones are raging and he concludes that he needs to find a girlfriend - but things soon get competitive when he and Uncle Andy vie for the attentions of Lex.
Andy stumbles into a drug-fuelled whirlwind romance with singer Jasmine and suddenly finds himself engaged. Errol lets a girl think he is 'experienced' in an attempt to look cool, and Sam has to find a way of telling the family some life-changing news.
Unfortunately, Bruce's mother and brother are coming to visit and everyone is struggling with whether to clear the air or hold on to their secrets. It isn't long before the lies spin out of control and Andy has to face up to some hard truths for the first time in his life.
Andy and Sam's chaotic parents, Neville and Jane, visit from Spain and announce they are getting a divorce. While Sam obsesses on the fact her mother still doesn't pay her attention, Andy schemes ways to keep his parents together in an attempt to prove he can make any relationship work. And Errol decides to play Ben and Bruce off each other to buy him a trip to Europe. Who will win the manipulation game?
When Melodie shows up at Andy's flat they finally hash it out and confess their feelings for each other. But, after a night of bliss, Melodie is gone.
Meanwhile, in his fantasy writing class, Errol spins a fantastical tale of Andy, now cast as a stable boy on a noble quest to find his long lost princess.
With the help of a young stable master Errol, the boys will encounter a slew of odd but familiar faces in this fantasy retelling of Uncle, and possibly help the real Andy get to the bottom of how he can win Melodie back.