Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Alone in the world and unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.
Dr. Shaun Murphy's attention to detail complicates his first day at St. Bonaventure Hospital. Meanwhile, Dr. Claire Browne learns a valuable lesson about honesty when confronted with a difficult diagnosis for her patient.
Dr. Neil Melendez and Dr. Jared Unger discover their patient isn't being completely honest with them which may cost him his chance at a life-saving surgery. Meanwhile, Dr. Claire Browne must learn to communicate with Dr. Shaun Murphy as they race back to St. Bonaventure Hospital with a donated organ.
Legalities abound when a husband and wife have to make a life-changing decision about their unborn baby; Dr. Shaun Murphy struggles to adjust to his new environment at home and takes a huge step forward with his colleagues.
While in the exam area of St. Bonaventure Hospital, Dr. Shaun Murphy encounters a young patient who looks eerily similar to his deceased brother, Steve. After discovering his parents have hidden his diagnosis from him, Shaun struggles to understand why he doesn't deserve to hear the truth about his own health. Meanwhile, the team can't figure out what keeps triggering their patients' increasingly severe allergic reactions and races to find the cause before the next one kills another patient.
During a robbery at the grocery mart Dr. Shaun Murphy is shopping at, his communication limitations puts lives at risk. Meanwhile, after Shaun's traumatic day, Dr. Aaron Glassman worries that he isn't doing enough to help Shaun.
As part of St. Bonaventure hospital's international humanitarian program, the team takes on the case of a young boy from the Congo who has severe congenital heart anomalies. Dr. Neil Melendez has doubts about the safety of the procedure, while Dr. Shaun Murphy works out the best course of action. Meanwhile, Murphy's latest encounter with his neighbor Lea has him confused.
Members of the hospital's surgical team are initially impressed with a charming young doctor, but his true character puts one of them in an awkward position at work. Meanwhile, Dr. Glassman feels Dr. Shaun Murphy needs a little more support with his personal life and suggests he meet with a therapist. However, Shaun is determined to show him that he can do it on his own.