The Big Bang Theory is a comedy about brilliant physicists, Leonard and Sheldon, who are the kind of "beautiful minds" that understand how the universe works. But none of that genius helps them interact with people, especially women. All this begins to change when a free-spirited beauty named Penny moves in next door. Sheldon, Leonard's roommate, is quite content spending his nights playing Klingon Boggle with their socially dysfunctional friends, fellow Cal Tech scientists Wolowitz and Koothrappali. However, Leonard sees in Penny a whole new universe of possibilities... including love.
Leonard and Wolowitz are furious after they learn Sheldon went to work with the military behind their backs. Also, while Bernadette is on bed rest, she asks Raj to do some digging when she suspects Ruchi is trying to steal her job.
When Sheldon kicks Amy out to work solo, she and Leonard bond during a series of science experiments. Also, Bert the geologist replaces Wolowitz in the band Footprints on the Moon, and Sheldon finds Penny a surprising source of scientific inspiration.
Koothrappali finds himself in the middle of domestic drama when he learns the woman he's dating, Nell, has a very upset husband, Oliver. Also, when Sheldon rents his old room back for a quiet place to work, he drives Leonard crazy by being a model tenant.
Penny gets the opportunity to host Bill Gates at work when his company wants to partner with her pharmaceutical company. Also, Leonard, Koothrappali and Wolowitz do everything in their power to meet him, while Sheldon thinks he is the victim of an April Fools prank.
When Leonard learns Sheldon is the president of the tenants association, he decides to run against him. Also, Bernadette encourages Wolowitz and Koothrappali to find the owner of a drone after they find it in the backyard.
A brilliant but reclusive scientist, Doctor Wolcott, invites Sheldon to his cabin in the middle of nowhere, and Leonard, Raj and Howard go along for the trip. Also, Penny and Bernadette improvise after Amy doesn't like the tame bachelorette party they planned for her.