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In the grip of his addictions, Patrick Melrose must fly to New York to collect his father's ashes. Over the course of a lost Manhattan weekend, Patrick's remorseless search for satisfaction, haunted by old acquaintances and insistent inner voices, sends him into a nightmarish spiral, including a disastrous date with the girl of his dreams. Alone in his hotel room later that night, he pushes body and mind to the very edge – desperate to stay one step ahead of his rapidly encroaching past.