NCIS: New Orleans is a drama about the local field office that investigates criminal cases involving military personnel in The Big Easy, a city known for its music, entertainment and decadence. Leading the team is Special Agent Dwayne Pride, a.k.a. "King," a native of New Orleans who is driven by his need to do what is right. Working with Pride is Special Agent Christopher LaSalle, who plays hard but works harder and former ATF agent Sonja Percy, who is still adjusting to the team after years of solo undercover assignments. Supporting them is coroner Dr. Loretta Wade, who is as eccentric as she is smart; her brilliant, quirky Forensic Scientist, Sebastian Lund; and Investigative Computer Specialist Patton Plame, an animated and talented hacker. New to the team is Special Agent Tammy Gregorio, a tough, acerbic FBI agent with a mysterious past in New Orleans, who is sent from D.C. to investigate the NCIS team, but also work with Pride when high-risk cases threaten the city. This colorful city that harbors a dark side is a magnet for service personnel on leave, and when overindulgence is followed by trouble, Pride's team is at its best
While Pride remains on probation six weeks after his rogue takedown of the corrupt Mayor Hamilton, his team is closely monitored by Supervisory Special Agent Paula Boyd. Also, when the FBI arrives to run lead on a case involving a stolen big rig of nuclear waste, the team must secretly investigate from the sidelines.
Pride and his team join forces with FBI Director Isler after a Russian operative, who's in the states to provide intelligence on sleeper agents, disappears after his Navy escort is murdered. Also, Tammy partners with former sleeper agent Eva Azarova to locate the missing operative who Eva has known since childhood.
The NCIS team investigates the copycat murder of an unsolved case from 150 years ago that spawned a legendary New Orleans ghost story. Also, Gregorio is spooked when the case is connected to a recent séance and a local medium.
Sebastian is placed on administrative leave after his response in a foot chase to apprehend a high value fugitive is questioned by the FBI. Also, while Pride and the team continue to track the high value target, they attempt to find a way to clear Sebastian's name.
Wade's son, Danny, calls Pride for help after he's attacked at his girlfriend's house and she is now missing. Also, the director of NCIS mandates that Pride meet with a therapist to discuss his process for solving cases.
After Rita Deveraux tells Pride that Douglas Hamilton is about to make a deal to get out of prison, Pride and the team rehash the Clearwater case in hopes of locating his mystery partner and spoiling his bargaining chip.
Sebastian receives a plea for help from his high school friend Adrian Conner after her business partner is killed at the Crescent City Gaming Convention. Also, FBI Special Agent Raymond Isler believes Adrian is a hacker the Cyber Crimes division has been tracking for years.
A petty officer's murder leads the team to a family-owned night club where Pride's mother used to perform weekly. Also, Lasalle must urgently return home to Alabama after receiving an unexpected call from his family.
The NCIS team investigates the murder of a petty officer who was in town to help a refugee family being recruited by terrorists. Also, Wade works on the special election campaign for Mayor Zahra Taylor that takes place during Mardi Gras.
FBI Special Agent Raymond Isler asks Pride for help with an off-the-books opioids theft investigation he is personally invested in. Also, Percy is sent undercover as a getaway driver with Isler as the muscle for a job tied to the case.
Percy and Lasalle go undercover at a high-stakes, underground poker game after the organizer targets players with access to a naval research laboratory. Also, Laurel Pride visits her dad during spring break to discuss options after her upcoming graduation.