Life In Pieces is a single-camera comedy about one big happy family and their sometimes awkward, often hilarious and ultimately beautiful milestone moments as told by its various members. Of the three siblings, middle child Matt may have just found his true love, his co-worker, Colleen; his coddled youngest brother, Greg, and his wife, Jen, are overwhelmed by the birth of their first child; and the eldest, Heather, and her husband, Tim, are dreading their impending empty nest so much, they're considering having another baby. Their parents are Joan, the family's adoring matriarch who would do anything for her kids - as long as she agrees with it - and John, the gregarious patriarch who's searching for ways to soften the blow of turning 70. As the family's lives unfold in four short stories each week, they try to savor these little pieces of time that flash by but stay with you forever, because these moments add up to what life's all about.
When the entire Hughes family moves into John and Joan's home after their kitchen is destroyed, their presence creates chaos for Joan. Also, Matt and Colleen are set to receive a huge monetary settlement from Colleen's fall off the motel balcony on their wedding night; John tries to get Sophia back on track when she starts misbehaving; Tyler and Clementine make a surprise announcement to the family; and Jen and Greg attempt to persuade Lark to get rid of her pacifier.
When Jen invites her boss, Paul, and his wife over to dinner to impress him, she and Greg can't remember his wife's name and scramble to avoid embarrassment. Also, Tim urges Tyler to start dating; Matt ends up having a nightmare about parenting after he and Colleen discuss having children; and Joan grows increasingly stressed about Heather living with her.
When Heather finds a map to a time capsule she buried with her brothers as kids, they all set out to find it and dig it up. Also, Jen learns she has a low car service rating so she books rides across the city to charm drivers and increase her score; Joan joins her neighbor's poker game in an effort to win an unusual prize; and John finally gets hearing aids but they aren't having the effect he was hoping for, on.
When Heather, Clementine and Jen offer to save Joan from the stress of preparing the Thanksgiving meal, the free time leaves Joan even more frazzled. Also, Greg has a boost of self-confidence after learning he has high levels of testosterone; Samantha keeps a secret from her family during Thanksgiving dinner; and John is determined to continue the tradition of using his old, unsafe knife to carve the turkey.
When Tim and Heather go to an expensive dinner to celebrate their anniversary, they are determined to finish every bite of their pricey 20-course meal. Also, Jen and Greg try to quickly potty-train Lark before her first day of preschool; Tyler gets jealous of the attention Clementine is getting at work; and Matt and Samantha team up for a "Middle Child Day" and go to a trapeze school.
When Heather tries to become Tyler's cool best friend, things take an awkward turn. Also, Jen and Greg get their first overnight away from Lark; Matt and Colleen regret returning their wedding presents for cash when they learn what John and Joan hid inside their gift; and Tim goes overboard when keeping a watchful eye on Samantha and her boyfriend.
When Jen and Greg hire Clementine as a part-time nanny for Lark and invite her to join them for dinner, the waitress mistakes Jen for Lark's grandmother. Also, Tyler's new girlfriend turns out to be Sophia's fourth grade teacher, John hires a questionable company to set up an escape room in his house, and Matt grows frustrated with Colleen when she blames a valet for stealing her lottery ticket.
When Sophia asks Matt and Colleen about having children, an animated sequence featuring the whole family as farm animals reveals that they have been struggling to have a baby. Also, Jen and Greg's new neighbors aren't as nice as they initially seem; Heather interferes with Tim's hiring process at the office; and the whole family surprises Joan at her book reading, to her chagrin.