When Jane Villanueva was a young girl, her grandmother, Alba, convinced her of two things: telenovelas are the highest form of entertainment, and women must protect their virginity at all costs. Now age 23, Jane is a driven young woman studying to become a teacher, nursing a dream to be a writer, and supporting herself with a job at a hot new Miami hotel. All the years of watching telenovelas with the two women who raised her - her sexy, young-at-heart mother, Xiomara, and her still-devout grandmother, Alba - have given Jane a slightly unrealistic view of romance. Still, she is determined not to make the same mistake her mother made - becoming an unwed mother at 16. Jane has managed to find a wonderful fiancé: a handsome, hard-working detective named Michael, who loves her enough to accept her detailed timeline for their future together and even her insistence on "saving herself" until they're married. All of Jane's meticulous life plans are turned upside down, however, when she sees her doctor for a routine check-up and is accidentally artificially inseminated with a specimen meant for the patient in the next room. Unbeknownst to her, the specimen belongs to Rafael, a reformed playboy and cancer survivor, who is not only the new owner of the hotel where Jane works but also a former summer crush of hers. A few weeks later, the unsuspecting Jane is faced with the most important decisions of her life. Will she continue with the pregnancy? How can she explain the situation to her fiancé and family? And what should she do about the wishes of the biological father, Rafael, and his scheming wife Petra? Though she has always tried to be the good girl who does the right thing, Jane's life has suddenly become as dramatic and complicated as the telenovelas she has always loved.
When Jane is reunited with her first love, Adam, she is shocked but happy to see him, however Xo and Alba are less thrilled that he is back. After Rafael loses ownership of the hotel to his sister, he finds himself at Jane's house, broke and homeless. Jane and Rafael learn that Petra has been found and they rush to her aide, but Anezka is nowhere to be found. Meanwhile, Xo and Rogelio wedded bliss is interrupted when they confront the realization that Darci is having Rogelio's baby and she wants full custody.
Jane's burgeoning relationship with Adam helps bring out her fun side and reminds her that she isn't just a mom. However, when Adam gets a job opportunity, he asks for Jane's opinion on if he should stay or go. Rogelio is facing issues with his co-star at work and things are about to get even worse for him. Xo is helping to take care of Darci to prove that Rogelio is committed to being a father to the baby. Meanwhile, Petra and Rafael are working together to try and buy back the hotel, but are running into trouble, causing tension between them.
Jane and Adam's relationship seems to be moving at hyper-speed, and Jane thinks that it might be time for him to meet Mateo, but Rafael is not happy with this idea. As the arrival of baby De LaVega Factor approaches, Rogelio's jealously of Darci's new boyfriend increases as well. Trying to be supportive, Xo encourages Rogelio to step up and be the father he was meant to be. Meanwhile, Rafael is determined to get his hotel and life back and will do whatever he has to do to make it happen.
When Jane learns that Rafael introduced Mateo to his new girlfriend, Katherine, without her consent she gets angry since she thinks Katherine has a negative influence on both Rafael and Mateo. Jane turns to Petra for help with the situation with Rafael, but Petra makes Jane an offer she can't refuse. Now that the baby is born, Rogelio and Darci struggle to choose a name for the baby they both agree on. Meanwhile, Xo is focused on growing the dance studio and decides to go into business with an unlikely foe.
When Adam reveals his dating past to Jane, the information puts a strain on their relationship. Lina seeks Jane's advice about whether she should get married and begs Jane to give her honest opinion about her fiancé. Petra hears some important information that could help Rafael get the hotel back, but Rafael is more concerned about his sister's well-being. Meanwhile, Xo asks Rogelio to consider having a medical procedure done, but Rogelio is very hesitant.