Based on Kem Nunn's novel, Chance is described as a provocative psychological thriller that focuses on Eldon Chance, a San Francisco-based forensic neuropsychiatrist who reluctantly gets sucked into a violent and dangerous world of mistaken identity, police corruption and mental illness. After an ill-advised decision regarding an alluring patient who may or may not be struggling with a multiple personality disorder, Chance finds himself in the crosshairs of her abusive spouse, who also happens to be a ruthless police detective. In over his head, Chance's decent into the city's shadowy underbelly, all while navigating the waters of a contentious divorce and the tribulations of his teenage daughter, soon spirals into an ever deepening exploration of one of mankind's final frontiers — the shadowy, undiscovered country of the human mind.
By day, Chance ministers to patients at the Victims of Violent Crime Unit; by night, he and D assault the victimizers. Detective Hynes blackmails Chance to use his skills to take down suspected serial killer Ryan Winter.
Chance and D grapple with news about Hynes. Chance accuses Winter of lying to him, but Winter learns he isn't the only one who's been dishonest. Nicole underestimates Christina. Kirsten tracks down a lead. Winter lays a trap.