American Gods follows Shadow Moon, a man serving three years in prison who is given an early release. Shadow Moon is hired as Mr. Wednesday's bodyguard and finds himself in a hidden world where a battle is brewing between the Old Gods and the New Gods.
After packing away his things, Shadow begins his cross-country trek with Wednesday and has an encounter with Lucy from I Love Lucy... on a TV screen. Meanwhile, Wednesday travels to Chicago to recruit an old "friend" to his cause.
In two viginettes, Anubus visits one of his followers. And a Middle Eastern salesman meets a fellow countryman in a New York taxicab. Meanwhile, Sweeney discovers that he gave his lucky coin to Shadow by mistake, and Shadow discovers how Wednesday raises his money.
Wednesday travels to Kentucky to recruit an Old God in his battle against the New Gods. However, the Goddess Easter is reluctant to help. Meanwhile, Technology Boy calls in his favor with Bilquis, and Laura learns who had her killed.