American Gods follows Shadow Moon, a man serving three years in prison who is given an early release. Shadow Moon is hired as Mr. Wednesday's bodyguard and finds himself in a hidden world where a battle is brewing between the Old Gods and the New Gods.
After packing away his things, Shadow begins his cross-country trek with Wednesday and has an encounter with Lucy from I Love Lucy... on a TV screen. Meanwhile, Wednesday travels to Chicago to recruit an old "friend" to his cause.
In two viginettes, Anubus visits one of his followers. And a Middle Eastern salesman meets a fellow countryman in a New York taxicab. Meanwhile, Sweeney discovers that he gave his lucky coin to Shadow by mistake, and Shadow discovers how Wednesday raises his money.