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Luke and Lizzy have been inseparable since childhood. Now all grown up and in their 30s, they have decided to have a baby - in a non-traditional way. Lizzy, who is gay, is really ready to become a mom and who better to be the dad than her best friend Luke. Then, just as Lizzy discovers she is actually pregnant, Luke surprises her with the news that he has fallen in love and married Prudence, a free-spirited, British beauty who was due to go back to England in a matter of days. Suddenly, a different kind of family is born and the three must learn how to make it work together.

Prudence moves in to Luke and Lizzy's apartment and her mess of boxes and belongings throws Lizzy for a loop. Prudence also pushes Lizzy to clean out a closet with her ex-girlfriend's things, which forces Lizzy to deal with some repressed feelings. Meanwhile, Luke is also adjusting to having Prudence in their lives and her marionette puppets are causing him some sleepless nights.

On a group trip to the gym, Lizzy spies her secret crush, Kate and with the help of Luke, and Prudence, she initiates a conversation that leads to some plans for group bowling. Later, Luke and Prudence help get Lizzy an appointment with the best OB-GYN in the city and Lizzy is ecstatic - until they arrive to a big surprise. Meanwhile, Prudence realizes that Lizzy's pregnancy is making her feel left out and Leisha helps her explain her feelings to Luke.

The ever-adventurous Prudence convinces Luke and Lizzy that they need to spice up their lives. Their idea of a good time is tackling the Farmers Market each week. Fearing that his new bride will find him too boring, Luke takes a chance at skydiving - with some disastrous results.

On a group trip to Las Vegas, Luke, Prudence and Lizzy visit the chapel where Nick and Prudence got married - only to discover that it was a sham and their marriage is not legal. Lizzy takes it upon herself to plan a spectacular new wedding with a special surprise. However, the group is in for an even bigger surprise about Prudence's past life in England.

After Luke learns about a secret that Prudence has been keeping from everyone, he disappears - leaving both their future and her immigration status in serious jeopardy. While Lizzy attempts to console Prudence and fix the situation, Luke hits the bars with Markus. And when all looks lost, Lizzy jumps in with a big, bold solution that will catch everyone by surprise.